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Quantity
MOTS-C 10mg
💧 Bacteriostatic Water (Included)
€75,00
One-time
- Mitochondrial biogenesis activation
- AMPK pathway stimulation
- Metabolic regulation enhancement
- Exercise mimetic properties
- Insulin sensitivity improvement
- Injection site reactions (redness, swelling)
- Mild gastrointestinal discomfort
- Transient fatigue
- Temporary appetite changes
This product is intended for laboratory research purposes only. Not for human consumption. Data from published preclinical and clinical studies.
Bacteriostatic Water
2 ml
Slowly drip along the vial wall. Do not shake — gently swirl.
Frequency
3× per week
Subcutaneous injection (abdomen, thigh). Mon, Wed, Fri.
Concentration
5 mg/ml
10 mg / 2 ml = 5 mg/ml. Every 10 units (0.1 ml) = 0.5 mg.
Titration
Not required
5–10 mg weekly (split across 3 doses).
Storage:Before reconstitution, store refrigerated (2–8 °C) or frozen (-20 °C). After reconstitution, keep refrigerated and use within 28 days. Protect from direct sunlight.
MOTS-C is a mitochondrial-derived peptide (MDP) encoded within the 12S rRNA gene of mitochondrial DNA. Discovered in 2012 by researchers at the University of Southern California, MOTS-C is recognized as a key regulator of metabolic homeostasis, acting as a mitochondrial signaling molecule that influences nuclear gene expression — a process termed "retrograde signaling."
Identified by Dr. Changhan David Lee and colleagues in 2012, MOTS-C was the first mitochondrial-derived peptide shown to have systemic metabolic effects. Published in Cell Metabolism, the discovery challenged the view that mitochondria are passive energy producers, revealing them as active regulators of cellular metabolism through encoded peptides. Since then, MOTS-C has become a major focus in aging, metabolic disease, and exercise physiology research.
MOTS-C has been studied extensively in preclinical and clinical settings. Here's what the published data shows:
Key Areas:
- Metabolic Regulation — MOTS-C activates AMPK and regulates cellular metabolism by targeting the folate cycle and de novo purine biosynthesis pathway. Studies show it improves glucose uptake and insulin sensitivity.
- Exercise Mimetic — Research demonstrates MOTS-C levels increase during exercise in humans. Exogenous MOTS-C administration in animal models improves physical performance and endurance capacity.
- Aging & Longevity — MOTS-C levels decline with age. Supplementation in aged mice improved physical capacity, metabolic health, and overall healthspan markers.
- Stress Response — MOTS-C translocates to the nucleus during metabolic stress, directly regulating adaptive nuclear gene expression to maintain cellular homeostasis.
These results come from peer-reviewed studies published in leading medical journals. MOTS-C is one of the most actively researched mitochondrial-derived peptides, with growing evidence supporting its role in metabolic regulation, exercise physiology, and aging.
Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. — Cell Metab. 2015Kim SJ, et al. Mitochondrial peptide MOTS-c integrates stress responses and physical activity. — Cell Metab. 2018Reynolds JC, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. — Nat Commun. 2021
Frequently Asked Questions
Everything you want to know about MOTS-C and our research compounds.
MOTS-C is a 16-amino acid mitochondrial-derived peptide — one of only a handful of peptides encoded by mitochondrial DNA rather than nuclear DNA. It acts as a retrograde signaling molecule, allowing mitochondria to communicate with the nucleus to regulate metabolic processes. This makes it fundamentally different from conventional peptides.
Unlike peptides that target single receptors, MOTS-C operates through the AMPK pathway and directly influences nuclear gene expression from within the cell. It functions as an exercise mimetic — reproducing some metabolic benefits of physical activity at the cellular level.
Every single batch undergoes independent third-party testing via HPLC and mass spectrometry — the gold standard in peptide analysis. We guarantee 99%+ purity on every vial. Certificates of Analysis are available for download directly on this page.
Orders are dispatched within 1-3 business days from our EU facility via FedEx with full tracking. EU delivery takes 1-3 days, US 2-4 days, Middle East 2-4 days. Every package is temperature-controlled and discreetly packed.
Each vial contains exactly 10mg of lyophilized (freeze-dried) MOTS-C peptide in powder form. Lyophilization ensures maximum stability — the powder remains potent for up to 2 years when stored at -20°C. After reconstitution with bacteriostatic water, refrigerate at 2-8°C and use within 4 weeks.
Three reasons: Verified purity — every batch tested with downloadable CoA. EU-manufactured — synthesized under strict pharmaceutical-grade conditions. Photo proof — we send you a photo of your exact order before it ships.
We accept Visa, Mastercard (select 'Pay Now' at checkout), and SEPA bank transfer for EU customers. All transactions are processed securely.
All products are sold strictly for laboratory and research purposes. They are not intended for human or animal consumption. Bionic Labs operates as a licensed chemical supplier within the EU.
Customer Reviews
5.0 — Based on 23 reviews
MK
Martin K. 🇩🇪✅ Verified Buyer
Excellent Quality Peptide
MOTS-C arrived quickly and was exactly as described. Purity matched the CoA perfectly. My metabolic research has been progressing well with this batch. Bionic Labs is my go-to for mitochondrial peptides.
JW
James W. 🇬🇧✅ Verified Buyer
Great for AMPK Research
Been using this for AMPK pathway studies and the results have been consistent. Shipping was fast to the UK, packaging was professional and discreet.
SK
Sophie K. 🇳🇱✅ Verified Buyer
MOTS-C 10mg
The product is great. It arrived early, and the packaging was intact. I was extremely impressed with the quality and even more so with the customer service I have received. Using it for mitochondrial-derived peptide research and the results are very promising.
LM
Lars M. 🇸🇪✅ Verified Buyer
Fast Delivery
To have MOTS-C available at this purity level is amazing. Shipping was quick to Sweden!
OP
Oliver P. 🇬🇧✅ Verified Buyer
Awesome! Best Quality
Bionic Labs never disappoints. Best in the business for research-grade peptides.
PD
Pierre D. 🇫🇷✅ Verified Buyer
Great Quality
Great quality product, professional customer service. My exercise physiology research has gone smoothly with this batch.
MR
Marco R. 🇮🇹✅ Verified Buyer
Ordering Online Was Easy
Ordering online was easy, user-friendly! Shipping was fast. Email communication from Bionic Labs was very convenient and reassuring! I really appreciate this!!
NB
Niklas B. 🇩🇰✅ Verified Buyer
Great Price and Product
Shipped quickly and received exactly what I needed for my metabolic research. Thanks.
HV
Henrik V. 🇦🇹✅ Verified Buyer
MOTS-C Peptide
Works great for mitochondrial peptide research. Purity is excellent.
FB
Florian B. 🇨🇭✅ Verified Buyer
Excellent Choice
So far I am very pleased with the product. Highest quality available for mitochondrial-derived peptide research.
JK
Jan K. 🇵🇱✅ Verified Buyer
Exactly What I Was Looking For
Got my order quick and everything was correct. AMPK pathway research is progressing well. Will order again soon.
AT
Ana T. 🇵🇹✅ Verified Buyer
Fantastic!
Product was shipped very quickly and securely. As described!
DH
David H. 🇬🇧✅ Verified Buyer
MOTS-C 10mg
Works great. Metabolic research going well with this peptide.
CC
Cristian C. 🇷🇴✅ Verified Buyer
Go to Supplier!
Go to Supplier! Best around in my experience for research peptides.
TJ
Tomas J. 🇪🇸✅ Verified Buyer
MOTS-C Peptide
Legit peps. Works great for metabolic and exercise physiology studies!
ER
Erik R. 🇳🇴✅ Verified Buyer
Love the Product
Love this peptide, great for mitochondrial research applications
AP
Adriaan P. 🇧🇪✅ Verified Buyer
Review
Excellent product, exactly as described on the CoA
SS
Stefan S. 🇩🇪✅ Verified Buyer
Love It!
Quality, timely delivery, consistent product batch after batch
AG
Andreas G. 🇮🇹✅ Verified Buyer
Good
Good, noticeable results in my metabolic research protocols
JJ
Javier J. 🇪🇸✅ Verified Buyer
Product Was As Advertised
Shipping was quick and ordering was easy.
GS
Giovanni S. 🇨🇿✅ Verified Buyer
Best Quality
Fast shipping, great for my exercise mimetic research
JH
Joost H. 🇳🇱✅ Verified Buyer
So Far So Good
So far so good, will update after a full research cycle. MOTS-C purity is excellent.
MD
Matej D. 🇭🇷✅ Verified Buyer
Top Notch
Excellent quality for mitochondrial peptide research. Bionic Labs is my trusted supplier.
MOTS-C 10mg
💧 Bacteriostatic Water (Included)
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